Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.80 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PLD2 | O14939 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | C5 | P01031 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628025 | 0.93 | ESR1 (0.76) | ESR1ESR2MEN1PLD2KDM1A | |
| SCHEMBL8625838 | 0.92 | ESR1 (0.65) | ESR1ESR2LMNACNR1 | |
| SCHEMBL7104864 | 0.89 | ESR1 (1.00) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL7075690 | 0.86 | TUBB4A (0.60) | ESR1ESR2CNR1HSD17B10 | |
| SCHEMBL11547223 | 0.86 | ESR1 (0.63) | ESR1ESR2MEN1PLD2KDM1A | |
| SCHEMBL15660902 | 0.84 | ESR1 (0.85) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL8340581 | 0.84 | ESR1 (0.74) | ESR1ESR2LMNA | |
| SCHEMBL7075381 | 0.84 | ESR1 (0.72) | ESR1ESR2MEN1PLD2KDM1A | |
| SCHEMBL11548512 | 0.83 | CNR1 (0.71) | ESR1ESR2CNR1TDP1 | |
| SCHEMBL7075664 | 0.83 | ESR1 (0.74) | ESR1ESR2MEN1PLD2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780648-A | Benzothiophene compounds, and uses formulations thereof | ELI LILLY AND COMPANY (US) | 1998-07-14 | — | — | US | disclosed |