Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172629 | 0.87 | PTPN1 (0.58) | PTPN1FFAR1SIRT2CA2MEN1 | |
| SCHEMBL8340297 | 0.81 | PTPN1 (0.48) | PTPN1CA2 | |
| SCHEMBL6968711 | 0.80 | PTPN1 (0.37) | PTPN1FFAR1CA2MEN1KMT2A | |
| SCHEMBL8336624 | 0.79 | MEN1 (0.42) | SIRT2MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL8208034 | 0.79 | PPARG (0.51) | FFAR1CA2KMT2AHTT | |
| SCHEMBL6968318 | 0.78 | TAAR1 (0.52) | PTPN1CA2MEN1KMT2AMTNR1A | |
| SCHEMBL8904473 | 0.77 | MEN1 (0.43) | PTPN1SIRT2MEN1KMT2AMTNR1A | |
| SCHEMBL8182392 | 0.77 | PTPN1 (0.66) | PTPN1FFAR1SIRT2CA2MEN1 | |
| SCHEMBL8172522 | 0.75 | CA2 (0.56) | PTPN1FFAR1SIRT2CA2MEN1 | |
| SCHEMBL6960498 | 0.75 | HDAC1 (0.45) | PTPN1SIRT2MEN1KMT2AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0783496-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-16 | — | — | EP | disclosed |
| WO-1997000249-A1 | HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-03 | — | — | WO | disclosed |
| WO-1996005186-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-22 | — | — | WO | disclosed |