Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8340613 | 0.92 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTNPSR1ALDH1A1GLA | |
| SCHEMBL8334662 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPTNPSR1ALDH1A1GLA | |
| SCHEMBL8338874 | 0.86 | SMN1; SMN2 (0.36) | SMN1; SMN2NPSR1L3MBTL1GAATDP1 | |
| SCHEMBL8340269 | 0.85 | SMPD1 (0.36) | SMN1; SMN2L3MBTL1GAATDP1 | |
| SCHEMBL8335997 | 0.85 | SMPD1 (0.36) | SMN1; SMN2L3MBTL1GAATDP1 | |
| SCHEMBL8339656 | 0.85 | SMPD1 (0.36) | SMN1; SMN2L3MBTL1GAATDP1 | |
| SCHEMBL8340185 | 0.83 | NPSR1 (0.35) | SMN1; SMN2NPSR1 | |
| SCHEMBL8335803 | 0.81 | L3MBTL1 (0.36) | MAPTLMNAKMT2AL3MBTL1GAA | |
| SCHEMBL8336116 | 0.81 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTNPSR1ALDH1A1GLA | |
| SCHEMBL8338169 | 0.79 | HIF1A (0.34) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |