Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.40 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115792 | 0.81 | GRIK1 (0.46) | MAPTGRIK1GRIK2GRIK3GRIK4 | |
| SCHEMBL8346075 | 0.79 | SLC22A6 (0.60) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8340369 | 0.78 | MAPT (0.41) | HTTMAPTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL8120416 | 0.78 | GRIK1 (0.42) | HTTMAPTLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL8107840 | 0.78 | GRIA1 (0.50) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8108014 | 0.76 | ALDH1A1 (0.40) | HTTMAPTLMNAALDH1A1 | |
| SCHEMBL8342187 | 0.76 | GRIK1 (0.50) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL8340372 | 0.76 | HTT (0.39) | HTTMAPTLMNAL3MBTL1GRIK1 | |
| SCHEMBL8342344 | 0.76 | GRIK1 (0.42) | MAPTGRIK1GRIK2GRIK3GRIK4 | |
| SCHEMBL8346022 | 0.75 | GRIK1 (0.58) | GRIK1GRIK2GRIK3GRIK4GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955461-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-09-21 | — | — | US | claimed |
| US-5750525-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-05-12 | — | — | US | claimed |