Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 12/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610073 | 0.79 | LMNA (0.57) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL7056726 | 0.78 | PDE4A (0.62) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL7407273 | 0.77 | LMNA (0.52) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL16208258 | 0.77 | LMNA (0.55) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL7050573 | 0.77 | PDE4A (0.61) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL14936651 | 0.75 | LMNA (0.54) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL14981193 | 0.74 | LMNA (0.56) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL3167884 | 0.74 | LMNA (0.57) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL309047 | 0.73 | PDE4A (0.60) | LMNARECQLPDE4APDE4BPDE4C | |
| SCHEMBL18384672 | 0.73 | PDE4A (0.55) | LMNARECQLPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549619-B1 | 4-AMINOBENZOFURAN COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICAL CORP (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2004009557-A1 | 6-AMINO-1H-INDAZOLE AND 4-AMINOBENZOFURAN COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |