SCHEMBL8342338

SCHEMBL8342338

Nc1ncnc2[nH]c(Br)nc12.Nc1ncnc2[nH]c(S)nc12

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 12/20 0.49
ADORA1 P30542 12/20 0.49
ADORA2B P29275 10/20 0.36
ADORA3 P0DMS8 8/20 0.34
ERAP1 Q9NZ08 1/20 0.33
PI4KA P42356 2/20 0.33
PI4K2B Q8TCG2 2/20 0.33
PI4K2A Q9BTU6 2/20 0.33
PI4KB Q9UBF8 2/20 0.33
NUDT1 P36639 2/20 0.32
LIMK1 P53667 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL159639 0.89 ADORA2A (0.40) ADORA2AADORA1ADORA2BERAP1PI4KA
SCHEMBL8565 0.89 ADORA2A (0.58) ADORA2AADORA1ADORA2BADORA3ERAP1
Pyrophosphoric Acid SCHEMBL6065977 0.75 ADORA2A (0.44) ADORA2AADORA1ADORA2BADORA3
SCHEMBL3799505 0.72
SCHEMBL8342350 0.72 ADORA2A (0.81) ADORA2AADORA1PI4KAPI4K2BPI4K2A
SCHEMBL42313 0.70 ADORA2A (0.42) ADORA2AADORA1ADORA2BADORA3ERAP1
SCHEMBL11367558 0.69
SCHEMBL17289600 0.69 ADORA2A (0.43) ADORA2AADORA1ADORA3
Water SCHEMBL3986353 0.68
Niacinamide SCHEMBL3281888 0.68 F7 (0.52) ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5872243-A Caged nucleotides MOLECULAR PROBES, INC. (US) 1999-02-16 US claimed