Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | DDO | Q99489 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722021 | 0.89 | ALDH1A1 (0.63) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL3174278 | 0.87 | ALDH1A1 (0.51) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL29897041 | 0.85 | ALDH1A1 (0.63) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL2399274 | 0.85 | ALDH1A1 (0.63) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL9654119 | 0.83 | KDM4E (0.57) | ALDH1A1HSD17B10HPGDKDM4EMEN1 | |
| SCHEMBL28911042 | 0.82 | KDM4E (0.51) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL7066817 | 0.81 | ALDH1A1 (0.52) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL8346159 | 0.81 | ALDH1A1 (0.51) | ALDH1A1HSD17B10MAPTHPGDUSP2 | |
| SCHEMBL8806930 | 0.81 | KDM4E (0.57) | ALDH1A1HSD17B10MAPTHPGDKDM4E | |
| SCHEMBL10704376 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HSD17B10MAPTHPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981525-A | FOR THERAPY OR PROPHYLAXIS OF OSTEOPOROSIS,TUMOURS, ULCERS, AUTOIMMUNE DISEASES, LIPIDEMIC DISORDERS, HYPERCHOLESTEROLEMIC AND ATHEROSCLEROTIC DISEASES, AIDS ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0802902-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | Smithkline Beecham S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021644-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | SMITHKLINE BEECHAM S.P.A. (IT) | 1996-07-18 | — | — | WO | disclosed |