Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.71 |
| ▸ | PDE4A | P27815 | 17/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6322995 | 0.87 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6323001 | 0.87 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6322447 | 0.87 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL14473185 | 0.87 | PDE4A (0.76) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL13790344 | 0.87 | PDE4A (0.76) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL8475654 | 0.84 | PDE4A (0.71) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7359794 | 0.84 | PDE4A (0.71) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7363153 | 0.84 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL84940 | 0.84 | PDE4A (0.69) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7359174 | 0.84 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003105902-A1 | TREATMENT FOR DEPRESSION AND ANXIETY BY THE COMBINATION OF A PDE IV INHIBITOR AND AN ANTIDEPRESSANT OR AN ANXIOLYTIC AGENT | PFIZER PRODUCTS INC. (US) | 2003-12-24 | — | — | WO | disclosed |
| WO-2003105815-A1 | COMBINATION OF PDE-V INHIBITORS AND NK1 ANTAGONISTS FOR THE TREATMENT OF DEPRESSION | PFIZER PRODUCTS INC. (US) | 2003-12-24 | — | — | WO | disclosed |