SCHEMBL8344464

SCHEMBL8344464

COc1ccc(-n2ncc3c(N/N=C/c4ccncc4)ncnc32)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 20/20 1.00
GSK3A P49840 3/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8344216 0.89 GSK3B (1.00) GSK3BGSK3A
Gw784752X SCHEMBL29534241 0.89 GSK3B (1.00) GSK3BGSK3A
Gw784752X SCHEMBL8344352 0.89 GSK3B (1.00) GSK3BGSK3A
SCHEMBL8344487 0.85 GSK3B (0.82) GSK3BGSK3A
SCHEMBL6205894 0.85 GSK3B (0.82) GSK3BGSK3A
SCHEMBL8339901 0.82 GSK3B (1.00) GSK3BGSK3A
SCHEMBL8344625 0.81 GSK3B (1.00) GSK3BGSK3A
SCHEMBL8339760 0.81 GSK3B (1.00) GSK3BGSK3A
SCHEMBL8344607 0.80 GSK3B (0.84) GSK3BGSK3A
SCHEMBL8344388 0.79 GSK3B (0.78) GSK3BGSK3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004009602-A1 PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2004-01-29 WO disclosed