Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | UBE2M | P61081 | 7/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808860 | 0.91 | USP2 (0.43) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8338160 | 0.89 | SLC6A2 (0.44) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8343649 | 0.88 | KDM4E (0.41) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8856425 | 0.88 | GCGR (0.37) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8856219 | 0.86 | UBE2M (0.39) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9056512 | 0.86 | KDM4E (0.36) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8341257 | 0.85 | SOAT1 (0.38) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8809049 | 0.85 | TP53 (0.42) | CYP1A2CYP2C19USP2ALDH1A1TP53 | |
| SCHEMBL8807728 | 0.85 | TP53 (0.42) | CYP1A2CYP2C19USP2ALDH1A1TP53 | |
| SCHEMBL29972806 | 0.85 | TP53 (0.42) | CYP1A2CYP2C19USP2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |