Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.44 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107840 | 0.96 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8342187 | 0.86 | GRIK1 (0.50) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8120416 | 0.86 | GRIK1 (0.42) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8343088 | 0.85 | GRIK1 (0.39) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL8342205 | 0.82 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL8115792 | 0.82 | GRIK1 (0.46) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8342344 | 0.81 | GRIK1 (0.42) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8342195 | 0.81 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Fanapanel SCHEMBL29352240 | 0.79 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| Fanapanel SCHEMBL353357 | 0.79 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955461-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-09-21 | — | — | US | disclosed |
| US-5750525-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-05-12 | — | — | US | disclosed |