Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924605 | 0.80 | HTR1A (0.43) | CYP19A1ALDH1A1MIF | |
| SCHEMBL31374633 | 0.79 | ALDH1A1 (0.52) | CYP19A1ALDH1A1KDM4ESMN1; SMN2DGAT1 | |
| SCHEMBL6644734 | 0.79 | ALDH1A1 (0.52) | CYP19A1ALDH1A1KDM4ESMN1; SMN2DGAT1 | |
| SCHEMBL923006 | 0.74 | CYP19A1 (0.46) | CYP19A1DGAT1 | |
| SCHEMBL924439 | 0.74 | CYP19A1 (0.46) | CYP19A1ALDH1A1MIFSMN1; SMN2 | |
| Bromide SCHEMBL8124970 | 0.73 | CYP19A1 (0.45) | CYP19A1DGAT1 | |
| SCHEMBL9836578 | 0.72 | HTR2C (0.47) | MIFHTTCYP1A2 | |
| SCHEMBL2877889 | 0.72 | MAPT (0.47) | ALDH1A1KDM4EGAAHPGDNPSR1 | |
| SCHEMBL27654667 | 0.71 | GAA (0.38) | ALDH1A1KDM4EGAASMN1; SMN2MAPT | |
| SCHEMBL9855381 | 0.70 | CYP26A1 (0.60) | CYP19A1ALDH1A1SMN1; SMN2DGAT1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935956-A | Pyridazine compounds | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-08-10 | — | — | US | disclosed |