SCHEMBL8345203

SCHEMBL8345203

FC(F)(F)Oc1ccc(-n2nnnc2Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 1/20 0.49
P2RX7 Q99572 2/20 0.44
L3MBTL1 Q9Y468 3/20 0.42
NPBWR1 P48145 2/20 0.42
MCHR1 Q99705 2/20 0.42
RXRA P19793 2/20 0.42
GRIN1 Q05586 2/20 0.42
GRIN2B Q13224 2/20 0.42
MAPT P10636 1/20 0.41
MAPK1 P28482 1/20 0.41
RECQL P46063 1/20 0.41
POLB P06746 1/20 0.39
PFKFB3 Q16875 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
NOTUM Q6P988 1/20 0.38
CACNA2D1 P54289 1/20 0.38
CACNA2D2 Q9NY47 1/20 0.38
SLC5A1 P13866 1/20 0.38
SLC5A2 P31639 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30620392 0.81 PRMT1 (0.49) PRMT1P2RX7L3MBTL1NPBWR1MCHR1
SCHEMBL8352171 0.78 MAPT (0.44) P2RX7L3MBTL1NPBWR1MAPTMEN1
SCHEMBL2056316 0.77 PRMT1 (0.61) PRMT1P2RX7L3MBTL1RXRAGRIN1
SCHEMBL8351721 0.75 ALDH1A1 (0.57) L3MBTL1MAPTMEN1KMT2AHTT
SCHEMBL4895319 0.75 MAPT (0.59) L3MBTL1MAPTNOTUMCYP1A2CYP2C19
SCHEMBL2094443 0.75 PRMT1 (0.47) PRMT1L3MBTL1NPBWR1MCHR1MAPT
SCHEMBL2094441 0.75 PRMT1 (0.56) PRMT1P2RX7L3MBTL1RXRAGRIN1
SCHEMBL2094445 0.75 PRMT1 (0.59) PRMT1L3MBTL1RXRAGRIN1GRIN2B
SCHEMBL18031144 0.74 ALDH1A1 (0.53) PRMT1L3MBTL1NPBWR1MCHR1MAPT
SCHEMBL18031622 0.74 PTGS2 (0.47) PRMT1L3MBTL1MAPTCACNA2D1SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9143170-A None JP disclosed
US-5981438-A HERBICIDE, INSECTICIDE AND PESTICIDE NIHON BAYER AGROCHEM K.K. (JP) 1999-11-09 US disclosed
EP-0855394-A1 1-Phenyl-5-anilinotetrazoles derivatives, their preparation and their use as microbiocides, insecticides and/or herbicides NIHON BAYER AGROCHEM K.K. (JP) 1998-07-29 EP disclosed
JP-H09143170-A TETRAZOLYLOXYACETAMIDES AND HERBICIDE NIPPON BAYERAGROCHEM KK 1997-06-03 JP disclosed