Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.75 |
| ▸ | ACVR1B | P36896 | 16/20 | 0.75 |
| ▸ | ACVRL1 | P37023 | 14/20 | 0.61 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.53 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955569 | 0.97 | TGFBR1 (0.71) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL8348960 | 0.89 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL5955131 | 0.89 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL8345663 | 0.88 | TGFBR1 (0.58) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL16134302 | 0.88 | TGFBR1 (0.73) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL16110716 | 0.88 | TGFBR1 (0.73) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL8346606 | 0.88 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL8346601 | 0.87 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL8346561 | 0.86 | TGFBR1 (0.66) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A | |
| SCHEMBL16879455 | 0.86 | TGFBR1 (1.00) | TGFBR1ACVR1BACVRL1ACVR1BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |