Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 16/20 | 0.58 |
| ▸ | ACVR1B | P36896 | 13/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 11/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.45 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348960 | 0.89 | TGFBR1 (0.59) | TGFBR1ACVR1BCYP3A4ACVRL1BMPR1A | |
| SCHEMBL8346601 | 0.89 | TGFBR1 (0.56) | TGFBR1ACVR1BCYP3A4ACVRL1BMPR1A | |
| SCHEMBL8346606 | 0.88 | TGFBR1 (0.57) | TGFBR1ACVR1BCYP3A4ACVRL1BMPR1A | |
| SCHEMBL8345302 | 0.88 | TGFBR1 (0.75) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8348955 | 0.88 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8344359 | 0.87 | TGFBR1 (0.59) | TGFBR1ACVR1BCYP3A4ACVRL1BMPR1A | |
| SCHEMBL8346612 | 0.87 | TGFBR1 (0.53) | TGFBR1ACVR1BCYP3A4ACVRL1BMPR1A | |
| SCHEMBL13649378 | 0.87 | TGFBR1 (0.55) | TGFBR1ACVR1BCYP3A4ACVRL1BMPR1A | |
| SCHEMBL5955569 | 0.85 | TGFBR1 (0.71) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8348082 | 0.85 | NUDT1 (0.55) | TGFBR1ACVR1BCYP3A4ACVRL1BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |