Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 13/20 | 0.63 |
| ▸ | MAPT | P10636 | 12/20 | 0.62 |
| ▸ | LMNA | P02545 | 10/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224500 | 0.86 | MAPT (0.65) | TP53MAPTLMNATDP1KDM4E | |
| SCHEMBL13082426 | 0.83 | NPC1 (0.56) | TP53MAPTLMNAKDM4EHTT | |
| SCHEMBL3879802 | 0.83 | KDM4E (0.71) | TP53MAPTLMNATDP1KDM4E | |
| SCHEMBL6205850 | 0.83 | TP53 (0.62) | TP53MAPTLMNATDP1KDM4E | |
| SCHEMBL24393325 | 0.82 | ALDH1A1 (0.67) | TP53MAPTLMNATDP1KDM4E | |
| SCHEMBL6204905 | 0.80 | MAPT (0.71) | TP53MAPTLMNAKDM4EHTT | |
| SCHEMBL840324 | 0.78 | NPC1 (0.71) | TP53MAPTLMNAKDM4EHTT | |
| SCHEMBL6267038 | 0.75 | MAPT (0.87) | TP53MAPTLMNAKDM4EHTT | |
| SCHEMBL24533690 | 0.73 | NPC1 (0.61) | TP53MAPTLMNATDP1KDM4E | |
| SCHEMBL839950 | 0.73 | SLC2A1 (0.60) | MAPTLMNAKDM4EHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |