Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 13/20 | 0.62 |
| ▸ | MAPT | P10636 | 12/20 | 0.62 |
| ▸ | LMNA | P02545 | 9/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224500 | 0.86 | MAPT (0.65) | TP53MAPTLMNATDP1MEN1 | |
| SCHEMBL3879802 | 0.83 | KDM4E (0.71) | TP53MAPTLMNATDP1MEN1 | |
| SCHEMBL6207703 | 0.83 | SLC2A1 (0.58) | TP53MAPTLMNAMEN1KMT2A | |
| SCHEMBL8345368 | 0.83 | TP53 (0.63) | TP53MAPTLMNATDP1MEN1 | |
| SCHEMBL6204755 | 0.83 | GSK3B (0.54) | TP53MAPTLMNAMEN1KMT2A | |
| SCHEMBL31337054 | 0.82 | ALDH1A1 (0.67) | TP53MAPTLMNATDP1MEN1 | |
| SCHEMBL6282033 | 0.82 | ALDH1A1 (0.67) | TP53MAPTLMNATDP1MEN1 | |
| SCHEMBL6206486 | 0.81 | GSK3B (0.60) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL6206071 | 0.81 | XDH (0.53) | TP53MAPTLMNAMEN1KMT2A | |
| SCHEMBL6204905 | 0.80 | MAPT (0.71) | TP53MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |