Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | BUB1 | O43683 | 11/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | CDC42BPG | Q6DT37 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346587 | 0.89 | TGFBR1 (0.47) | TGFBR1ACVR1BACVRL1BUB1PRKD3 | |
| SCHEMBL8347168 | 0.87 | TGFBR1 (0.47) | TGFBR1ACVR1BACVRL1BUB1PRKD3 | |
| SCHEMBL8348254 | 0.86 | TGFBR1 (0.43) | TGFBR1ACVR1BACVRL1BUB1PRKD3 | |
| SCHEMBL8347025 | 0.86 | TGFBR1 (0.43) | TGFBR1ACVR1BACVRL1BUB1PRKD3 | |
| SCHEMBL8345885 | 0.86 | TGFBR1 (0.45) | TGFBR1ACVR1BACVRL1BUB1PRKD3 | |
| SCHEMBL8348230 | 0.83 | TGFBR1 (0.46) | TGFBR1ACVR1BACVRL1BUB1PRKD3 | |
| SCHEMBL8346014 | 0.83 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1BUB1 | |
| SCHEMBL8346301 | 0.83 | TGFBR1 (0.47) | TGFBR1ACVR1BACVRL1BUB1 | |
| SCHEMBL8346247 | 0.83 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1BUB1 | |
| SCHEMBL8345332 | 0.82 | TGFBR1 (0.59) | TGFBR1BUB1PRKD3PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |