Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.59 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.59 |
| ▸ | BUB1 | O43683 | 18/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346587 | 0.87 | TGFBR1 (0.47) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8345889 | 0.86 | SCN9A (0.45) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8346012 | 0.86 | TGFBR1 (0.56) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8347168 | 0.85 | TGFBR1 (0.47) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8344361 | 0.85 | TGFBR1 (0.55) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8345684 | 0.85 | TGFBR1 (0.63) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8344963 | 0.84 | TGFBR1 (0.53) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8348254 | 0.84 | TGFBR1 (0.43) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8347025 | 0.84 | TGFBR1 (0.43) | TGFBR1PRKD3PRKD1PRKD2BUB1 | |
| SCHEMBL8345885 | 0.84 | TGFBR1 (0.45) | TGFBR1PRKD3PRKD1PRKD2BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |