Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.70 |
| ▸ | CNR1 | P21554 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345734 | 0.90 | KMT2A (0.78) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL6442706 | 0.88 | MEN1 (0.82) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL19427494 | 0.85 | RAB9A (0.73) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL8350552 | 0.85 | KMT2A (0.72) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL12316787 | 0.84 | KMT2A (0.82) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL14350895 | 0.81 | KMT2A (0.67) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL18196982 | 0.81 | MEN1 (0.71) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL13955868 | 0.81 | KMT2A (0.66) | MEN1KMT2AMAPTGAARAB9A | |
| SCHEMBL6564666 | 0.80 | MEN1 (0.54) | MEN1KMT2AMAPTCNR1GAA | |
| SCHEMBL9035434 | 0.80 | KMT2A (0.65) | MEN1KMT2AMAPTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069823-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2004-08-19 | — | — | WO | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |