SCHEMBL8345825

SCHEMBL8345825

Cc1csc(NC2CCC2)n1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.51
NPC1 O15118 5/20 0.50
ALDH1A1 P00352 2/20 0.48
SMN1; SMN2 Q16637 3/20 0.47
PI4KB Q9UBF8 1/20 0.45
TYR P14679 1/20 0.44
GAA P10253 3/20 0.43
KMT2A Q03164 2/20 0.43
MAPK1 P28482 1/20 0.43
GRM5 P41594 2/20 0.43
LCK P06239 1/20 0.41
ITK Q08881 1/20 0.41
MAPT P10636 3/20 0.41
MEN1 O00255 1/20 0.41
CNR2 P34972 1/20 0.41
HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13450604 0.96 RAB9A (0.55) RAB9ANPC1ALDH1A1SMN1; SMN2PI4KB
SCHEMBL5099245 0.95 RAB9A (0.58) RAB9ANPC1ALDH1A1SMN1; SMN2PI4KB
SCHEMBL29438377 0.95 RAB9A (0.58) RAB9ANPC1ALDH1A1SMN1; SMN2PI4KB
SCHEMBL29438374 0.95 RAB9A (0.58) RAB9ANPC1ALDH1A1SMN1; SMN2PI4KB
SCHEMBL15256162 0.92 RAB9A (0.50) RAB9ANPC1ALDH1A1SMN1; SMN2PI4KB
SCHEMBL22532118 0.80 GRM5 (0.44) RAB9ANPC1ALDH1A1SMN1; SMN2GAA
SCHEMBL13326581 0.78 PRKCI (0.44) RAB9ANPC1ALDH1A1SMN1; SMN2GAA
SCHEMBL26775804 0.78 PRKCI (0.44) RAB9ANPC1ALDH1A1SMN1; SMN2GAA
SCHEMBL3900029 0.77 ALDH1A1 (0.48) RAB9ANPC1ALDH1A1SMN1; SMN2GAA
SCHEMBL31461104 0.76 NPC1 (0.62) RAB9ANPC1ALDH1A1SMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1863833-B1 PROCESS FOR PREPARING MACROCYCLIC COMPOUNDS BOEHRINGER INGELHEIM INT (DE) 2013-09-18 EP disclosed
WO-2004009121-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING HEPATITIS C VIRAL PROTEASE INHIBITORS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2004-01-29 WO disclosed
WO-2003066103-A1 PHARMACEUTICAL COMPOSITIONS FOR HEPATITIS C VIRAL PROTEASE INHIBITORS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2003-08-14 WO disclosed