Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.46 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346612 | 0.85 | TGFBR1 (0.53) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8345576 | 0.84 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8346606 | 0.84 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8344445 | 0.83 | TGFBR1 (0.44) | TGFBR1ACVR1BACVRL1ACVR1PRKD3 | |
| SCHEMBL8345867 | 0.82 | TGFBR1 (0.51) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8344359 | 0.82 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8347168 | 0.82 | TGFBR1 (0.47) | TGFBR1ACVR1BACVRL1PRKD3PRKD1 | |
| SCHEMBL8348021 | 0.81 | TGFBR1 (0.51) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8348082 | 0.81 | NUDT1 (0.55) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8348197 | 0.81 | TGFBR1 (0.54) | TGFBR1ACVR1BACVRL1ACVR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024159-A1 | INHIBITORS OF TFGβ | SCIOS INC. (US) | 2004-03-25 | — | — | WO | disclosed |