SCHEMBL8346362

SCHEMBL8346362

O=C1CCSc2c(Cl)cc(Br)c(Cl)c21

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
VHL P40337 1/20 0.36
ELOC Q15369 1/20 0.36
ELOB Q15370 1/20 0.36
CA2 P00918 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8308058 0.84 VHL (0.34) VHLELOCELOB
SCHEMBL31028896 0.78 VHL (0.37) VHLELOCELOB
SCHEMBL8545225 0.73
SCHEMBL8545222 0.73
SCHEMBL8346491 0.73 VHL (0.41) VHLELOCELOB
SCHEMBL67587 0.70 VHL (0.54) VHLELOCELOBCA2
SCHEMBL30543398 0.70 VHL (0.54) VHLELOCELOBCA2
SCHEMBL23861146 0.68 VHL (0.37) VHLELOCELOB
SCHEMBL6725377 0.67 ALDH1A1 (0.32) CA2
SCHEMBL23861133 0.65 KDM4E (0.47) VHLELOCELOBCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5952266-A HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1999-09-14 US disclosed
EP-0836600-A1 HERBICIDAL KETALS AND SPIROCYCLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-04-22 EP disclosed
EP-0818455-A1 PYRAZOLE DERIVATIVES IDEMITSU KOSAN COMPANY LIMITED (JP) 1998-01-14 EP disclosed
WO-1997001550-A1 HERBICIDAL KETALS AND SPIROCYCLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-01-16 WO disclosed