Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.51 |
| ▸ | TACR2 | P21452 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8343307 | 0.91 | ITGB2 (0.50) | MMP2MMP9GHSR | |
| SCHEMBL8346990 | 0.89 | TACR1 (0.53) | TACR1TACR2MAPT | |
| SCHEMBL8343109 | 0.88 | TACR1 (0.55) | TACR1TACR2 | |
| SCHEMBL8345542 | 0.88 | TACR1 (0.55) | TACR1TACR2 | |
| SCHEMBL8345475 | 0.84 | TACR1 (0.42) | TACR1TACR2MMP2MMP9MMP8 | |
| SCHEMBL8346929 | 0.83 | TACR1 (0.56) | TACR1TACR2GHSR | |
| SCHEMBL8349377 | 0.82 | TACR1 (0.48) | TACR1TACR2MMP9MMP8GHSR | |
| SCHEMBL8344898 | 0.81 | TACR1 (0.52) | TACR1TACR2 | |
| SCHEMBL8345132 | 0.81 | TACR1 (0.53) | TACR1TACR2MMP9MMP8GHSR | |
| SCHEMBL7399209 | 0.80 | GHSR (0.47) | MMP2MMP9GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869489-A | TREATMENT OF INFLAMMATORY DISEASES, MIGRAINES AND ASTHMA | MERCK & CO., INC. (US) | 1999-02-09 | — | — | US | disclosed |