Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.47 |
| ▸ | HTR2A | P28223 | 8/20 | 0.47 |
| ▸ | HTR7 | P34969 | 8/20 | 0.47 |
| ▸ | HTR6 | P50406 | 8/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8348485 | 0.92 | DRD2 (0.44) | DRD2HTR2AHTR7HTR6ACHE | |
| SCHEMBL8351462 | 0.86 | DRD2 (0.47) | DRD2HTR2AHTR7HTR6ACHE | |
| SCHEMBL8712202 | 0.82 | DRD2 (0.43) | DRD2HTR2AHTR7HTR6ACHE | |
| SCHEMBL10634163 | 0.80 | ACHE (0.60) | DRD2HTR2AHTR7HTR6ACHE | |
| SCHEMBL8346604 | 0.80 | ACHE (0.49) | DRD2HTR2AHTR7HTR6ACHE | |
| SCHEMBL7357118 | 0.79 | HTR2A (0.41) | DRD2HTR2AHTR7HTR6 | |
| Hydrochloric Acid SCHEMBL10638219 | 0.79 | ACHE (0.59) | DRD2HTR2AHTR7HTR6ACHE | |
| Hydrochloric Acid SCHEMBL8350191 | 0.77 | HTR2A (0.46) | DRD2HTR2AHTR7HTR6ACHE | |
| SCHEMBL27464959 | 0.77 | DRD2 (0.41) | DRD2HTR2AHTR7HTR6ACHE | |
| SCHEMBL10640579 | 0.77 | DRD2 (0.46) | DRD2HTR2AHTR7HTR6ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919798-A | USEFUL AS ANTIPSYCHOTIC AND ANALGESIC AGENTS. | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-06 | — | — | US | disclosed |
| US-5889035-A | 1-(Arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-3-(heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5889004-A | PSYCHOLOGICAL DISORDERS, ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5874435-A | PSYCHOLOGICAL DISORDERS; ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5854243-A | 3-heteroaryl-1-pyrrolidinealkylthiols and derivatives thereof and their therapeutic utility | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5854263-A | 1- (1,4-benzodioxanyl)alkyl!-3-(heteroaryl) pyrrolidines and related compounds and their therapeutic utility | HOECHST MARION ROUSSEL, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5843977-A | (3-heteroaryl-1-pyrrolidinyl) alkoxy!-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility | HOECHST MARION ROSUEEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5843949-A | 1-(1H-indolyloxyalkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5840727-A | ANTIPSYCHOTICS, ANALGESICS | AVENTIS PHARMACEUTICALS INC. | 1998-11-24 | — | — | US | disclosed |
| US-5811430-A | 1 (2-pyrimidinyloxy) alkyl!-4- (heteroaryl) Piperidines and related compounds and their therapeutic utility | HOECHST MARION ROUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |
| US-5811435-A | 2- (4-heteroaryl-1-piperidinyl)alkyl!-1,3-dioxanes and related compounds and their therapeutic utility | HOECHST MARION RUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |
| US-5776963-A | ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-07 | — | — | US | disclosed |