Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1546504 | 0.89 | HTR1A (0.67) | HTR1ADRD2HTR2AHRH3 | |
| SCHEMBL1544789 | 0.89 | HTR1A (0.67) | HTR1ADRD2HTR2AHRH3 | |
| Hydrochloric Acid SCHEMBL8679257 | 0.82 | — | — | |
| SCHEMBL1545309 | 0.79 | ABCB11 (0.80) | HTR1ADRD2HTR2A | |
| SCHEMBL27335646 | 0.78 | ABCB11 (0.68) | HTR1ADRD2HTR2A | |
| SCHEMBL7773146 | 0.77 | HTR1A (0.49) | HTR1ADRD2HTR2AHRH3 | |
| Fumaric Acid SCHEMBL8467936 | 0.77 | ABCB11 (0.60) | HTR1ADRD2HTR2A | |
| SCHEMBL1544844 | 0.77 | ABCB11 (0.77) | HTR1ADRD2HTR2A | |
| SCHEMBL5992827 | 0.77 | HTR1A (0.56) | HTR1ADRD2HTR2AHRH3 | |
| SCHEMBL27345067 | 0.76 | ABCB11 (0.65) | HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919798-A | USEFUL AS ANTIPSYCHOTIC AND ANALGESIC AGENTS. | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-06 | — | — | US | disclosed |
| US-5889004-A | PSYCHOLOGICAL DISORDERS, ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5843977-A | (3-heteroaryl-1-pyrrolidinyl) alkoxy!-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility | HOECHST MARION ROSUEEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5843949-A | 1-(1H-indolyloxyalkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5840727-A | ANTIPSYCHOTICS, ANALGESICS | AVENTIS PHARMACEUTICALS INC. | 1998-11-24 | — | — | US | disclosed |
| US-5811430-A | 1 (2-pyrimidinyloxy) alkyl!-4- (heteroaryl) Piperidines and related compounds and their therapeutic utility | HOECHST MARION ROUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |