Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 6/20 | 0.46 |
| ▸ | RXRA | P19793 | 8/20 | 0.44 |
| ▸ | HNF4A | P41235 | 4/20 | 0.44 |
| ▸ | RXRB | P28702 | 4/20 | 0.43 |
| ▸ | RXRG | P48443 | 4/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | RARB | P10826 | 3/20 | 0.39 |
| ▸ | RARG | P13631 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347100 | 1.00 | PLK1 (0.46) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8345600 | 1.00 | PLK1 (0.46) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8347040 | 1.00 | PLK1 (0.46) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8353212 | 1.00 | PLK1 (0.46) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8345697 | 1.00 | PLK1 (0.46) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8349942 | 1.00 | PLK1 (0.46) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8352417 | 1.00 | PLK1 (0.46) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8347370 | 0.99 | PLK1 (0.44) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8347051 | 0.90 | RXRA (0.41) | PLK1RXRAHNF4ARXRBRXRG | |
| SCHEMBL8347392 | 0.90 | RXRA (0.41) | PLK1RXRAHNF4ARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935585-A | Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-08-10 | — | — | US | claimed |
| US-5935585-A | Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-08-10 | — | — | US | disclosed |