Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13028473 | 0.84 | TSHR (0.52) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL13721766 | 0.80 | TSHR (0.50) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL8349590 | 0.79 | ALDH1A1 (0.36) | ALDH1A1TSHR | |
| SCHEMBL483808 | 0.76 | TSHR (0.42) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL13720717 | 0.76 | TSHR (0.42) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL5705882 | 0.76 | TSHR (0.46) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL14194004 | 0.76 | TSHR (0.37) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL27811417 | 0.74 | TSHR (0.41) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL1899461 | 0.74 | TSHR (0.34) | ALDH1A1TP53HIF1ACYP3A4MAPK1 | |
| SCHEMBL9177552 | 0.73 | ALDH1A1 (0.38) | ALDH1A1TP53HIF1ACYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874464-A | ANTAGONIST OF PROTEIN KINASE C | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-02-23 | — | — | US | disclosed |