Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8348350 | 1.00 | CYSLTR1 (0.44) | CYSLTR1L3MBTL1PDE4BPPARGCNR2 | |
| SCHEMBL8348346 | 1.00 | CYSLTR1 (0.44) | CYSLTR1L3MBTL1PDE4BPPARGCNR2 | |
| SCHEMBL8353789 | 0.91 | GPBAR1 (0.42) | CYSLTR1PDE4BPPARGLTB4RALOX5 | |
| SCHEMBL8353780 | 0.91 | GPBAR1 (0.42) | CYSLTR1PDE4BPPARGLTB4RALOX5 | |
| SCHEMBL8353796 | 0.91 | GPBAR1 (0.42) | CYSLTR1PDE4BPPARGLTB4RALOX5 | |
| SCHEMBL8464670 | 0.86 | CYSLTR1 (0.64) | CYSLTR1LTB4RALOX5AP | |
| SCHEMBL8348539 | 0.86 | LTB4R (0.41) | PDE4BLTB4RALOX5 | |
| SCHEMBL8352997 | 0.86 | LTB4R (0.41) | PDE4BLTB4RALOX5 | |
| SCHEMBL8353000 | 0.86 | LTB4R (0.41) | PDE4BLTB4RALOX5 | |
| SCHEMBL8348530 | 0.86 | LTB4R (0.41) | PDE4BLTB4RALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952326-A | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5698550-A | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1997-12-16 | — | — | US | disclosed |
| EP-0441515-B1 | Tetralin and chroman derivatives in the treatment of asthma, arthritis and related diseases | PFIZER (US) | 1995-10-04 | — | — | EP | disclosed |