Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 3/20 | 0.50 |
| ▸ | TACR1 | P25103 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349962 | 0.93 | TACR2 (0.50) | TACR2TACR1TSHRALDH1A1 | |
| SCHEMBL8355974 | 0.91 | CA12 (0.42) | TACR2TACR1CYP2D6CYP3A4KMT2A | |
| SCHEMBL8355522 | 0.90 | TACR2 (0.53) | TACR2TACR1HTR1AALDH1A1 | |
| SCHEMBL8347396 | 0.89 | TACR2 (0.48) | TACR2TACR1CYP2D6CYP3A4 | |
| SCHEMBL8350232 | 0.88 | TACR2 (0.52) | TACR2TACR1TSHRKMT2AALDH1A1 | |
| SCHEMBL8347206 | 0.88 | TACR2 (0.51) | TACR2TACR1 | |
| SCHEMBL8356065 | 0.87 | KMT2A (0.39) | TACR2TACR1MEN1KMT2AALDH1A1 | |
| SCHEMBL8350410 | 0.85 | KMT2A (0.38) | TACR2TACR1KMT2A | |
| SCHEMBL8355501 | 0.85 | TACR2 (0.51) | TACR2TACR1MEN1KMT2A | |
| SCHEMBL8350132 | 0.84 | TACR2 (0.53) | TACR2TACR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |