Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 11/20 | 0.53 |
| ▸ | TACR1 | P25103 | 10/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8355501 | 0.90 | TACR2 (0.51) | TACR2TACR1TACR3HRH1 | |
| SCHEMBL8350232 | 0.90 | TACR2 (0.52) | TACR2TACR1TSHRTACR3HRH1 | |
| SCHEMBL8355758 | 0.86 | TACR2 (0.54) | TACR2TACR1TSHRHTT | |
| SCHEMBL8347206 | 0.86 | TACR2 (0.51) | TACR2TACR1TACR3HRH1 | |
| SCHEMBL8347396 | 0.85 | TACR2 (0.48) | TACR2TACR1TACR3HRH1 | |
| SCHEMBL8348494 | 0.84 | TACR2 (0.50) | TACR2TACR1TSHR | |
| SCHEMBL8349962 | 0.84 | TACR2 (0.50) | TACR2TACR1TSHRTACR3HRH1 | |
| SCHEMBL8355522 | 0.83 | TACR2 (0.53) | TACR2TACR1 | |
| SCHEMBL8636699 | 0.83 | SPR (0.40) | TACR2TACR1NPC1 | |
| SCHEMBL8355974 | 0.82 | CA12 (0.42) | TACR2TACR1TACR3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |