Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TACR2 | P21452 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 2/20 | 0.36 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8355974 | 0.91 | CA12 (0.42) | KMT2ATACR2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8347396 | 0.89 | TACR2 (0.48) | TACR2TACR1TACR3 | |
| SCHEMBL8347573 | 0.87 | USP2 (0.43) | KMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL8348494 | 0.87 | TACR2 (0.50) | KMT2ATACR2ALDH1A1MEN1TACR1 | |
| SCHEMBL8351409 | 0.86 | DRD2 (0.37) | KMT2AALDH1A1GPR183MAPTSLC6A2 | |
| SCHEMBL8350410 | 0.85 | KMT2A (0.38) | KMT2ATACR2TACR1TACR3SLC6A2 | |
| SCHEMBL8349962 | 0.84 | TACR2 (0.50) | TACR2ALDH1A1TACR1TACR3 | |
| SCHEMBL8351517 | 0.83 | SMN1; SMN2 (0.45) | KMT2ATACR2ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8636699 | 0.83 | SPR (0.40) | KMT2ATACR2TACR1HPGDSLC6A2 | |
| SCHEMBL8351833 | 0.82 | CCR5 (0.42) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861416-A | TREATMENT OF ASTHMA OR COUGH | MERRELL PHARMACEUTICALS INC. (US) | 1999-01-19 | — | — | US | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |