Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22725047 | 0.79 | PKM (0.38) | TSHR | |
| SCHEMBL8350029 | 0.70 | MAPK14 (0.38) | KMT2APOLBALDH1A1 | |
| SCHEMBL4470439 | 0.67 | DRD3 (0.36) | KMT2AMAPTHTTPOLBALDH1A1 | |
| SCHEMBL25343971 | 0.65 | PKM (0.51) | KMT2AMAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL30023522 | 0.65 | PKM (0.51) | KMT2AMAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL30023712 | 0.65 | DRD1 (0.46) | MAPTHTTTSHRPOLBKDM4E | |
| SCHEMBL24654438 | 0.64 | ALDH1A1 (0.35) | KMT2AMAPTTSHRPOLBKDM4E | |
| SCHEMBL19203509 | 0.64 | ALDH1A1 (0.48) | KMT2AL3MBTL1MAPTHTTPOLB | |
| SCHEMBL24289620 | 0.64 | HRH3 (0.47) | KMT2AMAPTHTTTSHRPOLB | |
| SCHEMBL27942049 | 0.64 | HSD17B10 (0.50) | L3MBTL1TSHRPOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004052847-A2 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |