Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 8/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448799 | 0.82 | PTGER4 (0.62) | PTGER4PTGER2MEN1KMT2A | |
| SCHEMBL4449431 | 0.82 | PTGER4 (0.57) | PTGER4PTGER2CYP1A2PDE4APDE4B | |
| SCHEMBL27512619 | 0.81 | KMT2A (0.56) | KMT2APDE4APDE4BPDE4DALDH1A1 | |
| SCHEMBL8297693 | 0.80 | PTGER4 (0.45) | PTGER4PTGER2MEN1MAPTPKM | |
| SCHEMBL27653388 | 0.77 | PTGER4 (0.58) | PTGER4PTGER2KMT2APDE4APDE4B | |
| SCHEMBL5749360 | 0.74 | L3MBTL1 (0.45) | PTGER4MEN1MAPTHTTKMT2A | |
| SCHEMBL2779885 | 0.73 | TDP1 (0.55) | PTGER4PTGER2MEN1KMT2ACYP1A2 | |
| SCHEMBL27512962 | 0.73 | KMT2A (0.51) | KMT2APDE4APDE4BPDE4DALDH1A1 | |
| SCHEMBL7181929 | 0.73 | PTGER4 (0.84) | PTGER4PTGER2MAPTKMT2ACYP1A2 | |
| SCHEMBL6062652 | 0.72 | PDE4B (0.59) | PTGER4PDE4APDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003068233-A1 | NICOTINAMIDE DERIVATIVES AND A TIOTROPIUM SALT IN COMBINATION FOR THE TREATMENT OF E.G. INFLAMMATORY, ALLERGIC AND RESPIRATORY DISEASES | PFIZER LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |