Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL8518097 | 0.97 | TSHR (0.64) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL4310722 | 0.88 | TSHR (0.84) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL7218802 | 0.85 | HPGD (0.73) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL10197843 | 0.83 | HPGD (0.71) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL29941490 | 0.83 | HPGD (0.71) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL1588162 | 0.82 | TSHR (0.69) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL1375290 | 0.81 | TSHR (0.68) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL4548025 | 0.81 | TSHR (1.00) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL20021992 | 0.81 | TSHR (0.68) | TSHRHPGDAKR1C1LMNANPC1 | |
| SCHEMBL31428791 | 0.81 | TSHR (0.68) | TSHRHPGDAKR1C1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703957-B2 | Phosphonic acid compounds as inhibitors of serine proteases | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-22 | — | — | US | disclosed |
| US-8703957-B2 | Phosphonic acid compounds as inhibitors of serine proteases | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-22 | — | — | US | disclosed |
| US-20130281407-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | JANSSEN PHARMACEUTICA NV (BE) | 2013-10-24 | — | — | US | disclosed |
| US-20130281407-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | JANSSEN PHARMACEUTICA NV (BE) | 2013-10-24 | — | — | US | disclosed |
| US-8497373-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497373-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8461195-B2 | Phosphonic acid compounds as inhibitors of serine proteases | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-06-11 | — | — | US | disclosed |
| US-8461195-B2 | Phosphonic acid compounds as inhibitors of serine proteases | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-06-11 | — | — | US | disclosed |
| US-8394804-B2 | Phosphonic acid compounds as inhibitors of serine proteases | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |
| US-8394804-B2 | Phosphonic acid compounds as inhibitors of serine proteases | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |
| US-20090118508-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-20090118508-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-20090118235-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-20090118235-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-20090118234-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-20090118504-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | GRECO MICHAEL N | 2009-05-07 | — | — | US | disclosed |
| US-7459461-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-7459461-B2 | Phosphonic acid compounds as inhibitors of serine proteases | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| WO-2003035654-A1 | PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-05-01 | — | — | WO | disclosed |
| CN-1204327-A | Pharmaceutically active quinazoline compounds | ASTRA PHARMA PROD (GB) | 1999-01-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118508-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | HPN, PRSS1, SERPINB1 | TSHR 4753/4885HPGD 919/4885AKR1C1 3145/4885 |
| US-20130281407-A1 | NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES | HPN, PRSS1, SERPINB1 | TSHR 4753/4885HPGD 919/4885AKR1C1 3145/4885 |
| US-20090118235-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | HPN, PRSS1, SERPINB1 | TSHR 4753/4885HPGD 919/4885AKR1C1 3145/4885 |
| US-20090118234-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | HPN, PRSS1, SERPINB1 | TSHR 4753/4885HPGD 919/4885AKR1C1 3145/4885 |
| US-20090118504-A1 | Novel phosphonic acid compounds as inhibitors of serine proteases | HPN, PRSS1, SERPINB1 | TSHR 4753/4885HPGD 919/4885AKR1C1 3145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.