Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | CDC25A | P30304 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351775 | 0.93 | MAPK8 (0.69) | MAPK8MAPK10KDM4EALDH1A1MAPT | |
| SCHEMBL4004296 | 0.88 | MAPK8 (0.72) | MAPK8MAPK10KDM4EALDH1A1MAPT | |
| SCHEMBL3999434 | 0.86 | MAPK8 (0.66) | MAPK8MAPK10KDM4EALDH1A1MAPT | |
| SCHEMBL3996393 | 0.85 | NPC1 (0.70) | MAPK8MAPK10KDM4EALDH1A1MAPT | |
| SCHEMBL4002795 | 0.84 | GRM4 (0.53) | MAPK8MAPK10JAK2SMN1; SMN2NPC1 | |
| SCHEMBL1518754 | 0.83 | MAPK8 (1.00) | MAPK8MAPK10KDM4EALDH1A1MAPT | |
| SCHEMBL4003048 | 0.82 | ABL1 (0.60) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3647264 | 0.82 | ALDH1A1 (0.68) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL4001863 | 0.80 | MAPT (0.67) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3997662 | 0.76 | ABL1 (0.59) | MAPK8MEN1KMT2AJAK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |