Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.69 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 13/20 | 0.53 |
| ▸ | NPC1 | O15118 | 12/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349353 | 0.93 | MAPK8 (0.71) | MAPK8MAPK10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1518754 | 0.82 | MAPK8 (1.00) | MAPK8MAPK10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3997662 | 0.82 | ABL1 (0.59) | MAPK8PTPN1PTPN2PTPN6PTPN11 | |
| SCHEMBL4004296 | 0.81 | MAPK8 (0.72) | MAPK8MAPK10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8350719 | 0.80 | SMN1; SMN2 (0.62) | RAB9ANPC1SMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL3647264 | 0.79 | ALDH1A1 (0.68) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3999434 | 0.79 | MAPK8 (0.66) | MAPK8MAPK10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3996393 | 0.78 | NPC1 (0.70) | MAPK8MAPK10RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7165404 | 0.76 | MAPK1 (0.60) | PTPN1PTPN2PTPN6PTPN11RAB9A | |
| SCHEMBL4002795 | 0.76 | GRM4 (0.53) | MAPK8MAPK10RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |