Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.60 |
| ▸ | GRN | P28799 | 1/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 2/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350078 | 0.93 | CTSK (0.69) | CTSKGRNSORT1CTSSPSMB5 | |
| SCHEMBL8349746 | 0.92 | CTSK (0.59) | CTSKGRNSORT1CTSSCCR1 | |
| SCHEMBL4043042 | 0.84 | CTSK (0.68) | CTSKCTSSCCR1CTSLPOLB | |
| SCHEMBL4041237 | 0.84 | CTSK (0.82) | CTSKCTSSCCR1RAB9APREP | |
| SCHEMBL4215661 | 0.84 | CTSK (0.82) | CTSKCTSSCCR1RAB9APREP | |
| SCHEMBL4215663 | 0.84 | CTSK (0.82) | CTSKCTSSCCR1RAB9APREP | |
| SCHEMBL5941468 | 0.84 | CTSK (0.82) | CTSKCTSSCCR1RAB9APREP | |
| SCHEMBL13909109 | 0.83 | CTSK (0.69) | CTSKGRNSORT1CTSSCCR1 | |
| SCHEMBL4219217 | 0.83 | CTSK (0.82) | CTSKCTSSCCR1CTSLPOLB | |
| SCHEMBL4041422 | 0.83 | CTSK (0.82) | CTSKCTSSCCR1CTSLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |