Sugi Predict

Sugi Predict / Compounds / SCHEMBL8350432

SCHEMBL8350432

SCHEMBL8350432

O=C(O)c1cc2ccccc2cc1C(=O)C(c1cccc2ccccc12)P(=O)(O)O

nearest known ligand 0.68

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ CTSG P08311 9/20 0.68
▸ CMA1 P23946 4/20 0.67
▸ ACP3 P15309 4/20 0.67
▸ MASP2 O00187 1/20 0.56
▸ NR4A1 P22736 1/20 0.45
▸ NR4A2 P43354 1/20 0.45
▸ NR4A3 Q92570 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.43
▸ IDO1 P14902 1/20 0.43
▸ CDC25B P30305 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10146826 0.91 CTSG (0.60) CTSGCMA1ACP3MASP2NR4A1
SCHEMBL8349344 0.82 CTSG (0.54) CTSGCMA1ACP3MASP2ALDH1A1
SCHEMBL8938011 0.81 CTSG (0.76) CTSGCMA1ACP3MASP2
SCHEMBL4140309 0.81 CMA1 (0.67) CTSGCMA1ACP3MASP2HSD17B10
SCHEMBL10146814 0.81 CTSG (0.53) CTSGCMA1ACP3MASP2ALDH1A1
SCHEMBL8290968 0.81 CTSG (1.00) CTSGCMA1ACP3MASP2
SCHEMBL4186282 0.80 CTSG (0.55) CTSGCMA1ACP3MASP2
SCHEMBL10146770 0.79 CTSG (0.59) CTSGCMA1ACP3MASP2
SCHEMBL4200589 0.79 NPC1 (0.56) CTSGCMA1ACP3MASP2
SCHEMBL2748880 0.78 CTSG (0.65) CTSGCMA1ACP3MASP2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8703957-B2 Phosphonic acid compounds as inhibitors of serine proteases JANSSEN PHARMACEUTICA NV (BE) 2014-04-22 — — US disclosed
US-8703957-B2 Phosphonic acid compounds as inhibitors of serine proteases JANSSEN PHARMACEUTICA NV (BE) 2014-04-22 — — US disclosed
US-20130281407-A1 NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES JANSSEN PHARMACEUTICA NV (BE) 2013-10-24 — — US disclosed
US-20130281407-A1 NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES JANSSEN PHARMACEUTICA NV (BE) 2013-10-24 — — US disclosed
US-8497373-B2 Phosphonic acid compounds as inhibitors of serine proteases ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2013-07-30 — — US disclosed
US-8497373-B2 Phosphonic acid compounds as inhibitors of serine proteases ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2013-07-30 — — US disclosed
US-8461195-B2 Phosphonic acid compounds as inhibitors of serine proteases JANSSEN PHARMACEUTICA N.V. (BE) 2013-06-11 — — US disclosed
US-8461195-B2 Phosphonic acid compounds as inhibitors of serine proteases JANSSEN PHARMACEUTICA N.V. (BE) 2013-06-11 — — US disclosed
US-8394804-B2 Phosphonic acid compounds as inhibitors of serine proteases JANSSEN PHARMACEUTICA N.V. (BE) 2013-03-12 — — US disclosed
US-8394804-B2 Phosphonic acid compounds as inhibitors of serine proteases JANSSEN PHARMACEUTICA N.V. (BE) 2013-03-12 — — US disclosed
US-20090118508-A1 Novel phosphonic acid compounds as inhibitors of serine proteases GRECO MICHAEL N 2009-05-07 — — US disclosed
US-20090118508-A1 Novel phosphonic acid compounds as inhibitors of serine proteases GRECO MICHAEL N 2009-05-07 — — US disclosed
US-20090118235-A1 Novel phosphonic acid compounds as inhibitors of serine proteases GRECO MICHAEL N 2009-05-07 — — US disclosed
US-20090118235-A1 Novel phosphonic acid compounds as inhibitors of serine proteases GRECO MICHAEL N 2009-05-07 — — US disclosed
US-20090118504-A1 Novel phosphonic acid compounds as inhibitors of serine proteases GRECO MICHAEL N 2009-05-07 — — US disclosed
US-20090118234-A1 Novel phosphonic acid compounds as inhibitors of serine proteases GRECO MICHAEL N 2009-05-07 — — US disclosed
US-20090118234-A1 Novel phosphonic acid compounds as inhibitors of serine proteases GRECO MICHAEL N 2009-05-07 — — US disclosed
US-7459461-B2 Phosphonic acid compounds as inhibitors of serine proteases ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2008-12-02 — — US disclosed
US-7459461-B2 Phosphonic acid compounds as inhibitors of serine proteases ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2008-12-02 — — US disclosed
WO-2003035654-A1 PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-05-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090118508-A1 Novel phosphonic acid compounds as inhibitors of serine proteases HPN, PRSS1, SERPINB1 CTSG 251/4885CMA1 137/4885ACP3 81/4885
US-20130281407-A1 NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES HPN, PRSS1, SERPINB1 CTSG 251/4885CMA1 137/4885ACP3 81/4885
US-20090118235-A1 Novel phosphonic acid compounds as inhibitors of serine proteases HPN, PRSS1, SERPINB1 CTSG 251/4885CMA1 137/4885ACP3 81/4885
US-20090118234-A1 Novel phosphonic acid compounds as inhibitors of serine proteases HPN, PRSS1, SERPINB1 CTSG 251/4885CMA1 137/4885ACP3 81/4885
US-20090118504-A1 Novel phosphonic acid compounds as inhibitors of serine proteases HPN, PRSS1, SERPINB1 CTSG 251/4885CMA1 137/4885ACP3 81/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.