Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GLS | O94925 | 7/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350083 | 0.95 | HTT (0.66) | HTTHSD17B10POLBALDH1A1GLS | |
| SCHEMBL1241823 | 0.89 | HTT (0.70) | HTTHSD17B10POLBALDH1A1GLS | |
| SCHEMBL15742353 | 0.85 | POLB (0.59) | HTTHSD17B10POLBALDH1A1GLS | |
| SCHEMBL24259191 | 0.83 | GLS (0.48) | HTTHSD17B10ALDH1A1GLS | |
| SCHEMBL8358314 | 0.78 | HTT (1.00) | HTTHSD17B10POLBALDH1A1F2 | |
| SCHEMBL14975757 | 0.77 | ALDH1A1 (0.95) | POLBALDH1A1GLSF2 | |
| SCHEMBL14986945 | 0.75 | ALDH1A1 (1.00) | POLBALDH1A1GLSF2 | |
| SCHEMBL161099 | 0.74 | GLS (0.46) | HTTHSD17B10GLS | |
| SCHEMBL11418576 | 0.73 | POLB (0.64) | HTTHSD17B10POLBALDH1A1GLS | |
| SCHEMBL14977428 | 0.73 | ALDH1A1 (0.86) | POLBALDH1A1GLSF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |