Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4001863 | 0.93 | MAPT (0.67) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL8353816 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL4000628 | 0.82 | ABL1 (0.69) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL8351775 | 0.80 | MAPK8 (0.69) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL13874759 | 0.78 | MAPT (1.00) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL2941787 | 0.76 | ABL1 (0.75) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL4002795 | 0.75 | GRM4 (0.53) | SMN1; SMN2NPC1RAB9AABL1SRC | |
| SCHEMBL8351597 | 0.75 | CYP2D6 (0.52) | SMN1; SMN2MAPTKMT2ALMNANPC1 | |
| SCHEMBL19392293 | 0.74 | NPC1 (0.89) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL8349353 | 0.73 | MAPK8 (0.71) | SMN1; SMN2MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312227-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2004041789-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-21 | — | — | WO | disclosed |