Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP6V1B1 | P15313 | 5/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | ATP6AP1 | Q15904 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350872 | 1.00 | ATP6V1B1 (0.67) | ATP6V1B1DRD2DRD3ATP6AP1KDM4E | |
| SCHEMBL8350863 | 1.00 | ATP6V1B1 (0.67) | ATP6V1B1DRD2DRD3ATP6AP1KDM4E | |
| SCHEMBL6291678 | 0.90 | ATP6V1B1 (0.75) | ATP6V1B1DRD2DRD3ATP6AP1KDM4E | |
| SCHEMBL6291675 | 0.90 | ATP6V1B1 (0.75) | ATP6V1B1DRD2DRD3ATP6AP1KDM4E | |
| SCHEMBL6291679 | 0.90 | ATP6V1B1 (0.75) | ATP6V1B1DRD2DRD3ATP6AP1KDM4E | |
| SCHEMBL8346962 | 0.84 | ATP6V1B1 (0.68) | ATP6V1B1ATP6AP1KDM4EALDH1A1ACKR3 | |
| SCHEMBL8346964 | 0.84 | ATP6V1B1 (0.68) | ATP6V1B1ATP6AP1KDM4EALDH1A1ACKR3 | |
| SCHEMBL8346958 | 0.84 | ATP6V1B1 (0.68) | ATP6V1B1ATP6AP1KDM4EALDH1A1ACKR3 | |
| SCHEMBL8343510 | 0.81 | ATP6V1B1 (0.71) | ATP6V1B1ATP6AP1KDM4EALDH1A1MAPT | |
| SCHEMBL8343513 | 0.81 | ATP6V1B1 (0.71) | ATP6V1B1ATP6AP1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981525-A | FOR THERAPY OR PROPHYLAXIS OF OSTEOPOROSIS,TUMOURS, ULCERS, AUTOIMMUNE DISEASES, LIPIDEMIC DISORDERS, HYPERCHOLESTEROLEMIC AND ATHEROSCLEROTIC DISEASES, AIDS ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0802902-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | Smithkline Beecham S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021644-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | SMITHKLINE BEECHAM S.P.A. (IT) | 1996-07-18 | — | — | WO | disclosed |