Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP6V1B1 | P15313 | 4/20 | 0.75 |
| ▸ | ATP6AP1 | Q15904 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291678 | 1.00 | ATP6V1B1 (0.75) | ATP6V1B1ATP6AP1DRD2DRD3MEN1 | |
| SCHEMBL6291679 | 1.00 | ATP6V1B1 (0.75) | ATP6V1B1ATP6AP1DRD2DRD3MEN1 | |
| SCHEMBL8350868 | 0.90 | ATP6V1B1 (0.67) | ATP6V1B1ATP6AP1DRD2DRD3HTR2C | |
| SCHEMBL8350872 | 0.90 | ATP6V1B1 (0.67) | ATP6V1B1ATP6AP1DRD2DRD3HTR2C | |
| SCHEMBL8350863 | 0.90 | ATP6V1B1 (0.67) | ATP6V1B1ATP6AP1DRD2DRD3HTR2C | |
| SCHEMBL8343521 | 0.88 | ATP6V1B1 (0.80) | ATP6V1B1ATP6AP1MEN1KMT2AALDH1A1 | |
| SCHEMBL8346958 | 0.81 | ATP6V1B1 (0.68) | ATP6V1B1ATP6AP1MEN1KMT2AACKR3 | |
| SCHEMBL8346962 | 0.81 | ATP6V1B1 (0.68) | ATP6V1B1ATP6AP1MEN1KMT2AACKR3 | |
| SCHEMBL8346964 | 0.81 | ATP6V1B1 (0.68) | ATP6V1B1ATP6AP1MEN1KMT2AACKR3 | |
| SCHEMBL8343510 | 0.80 | ATP6V1B1 (0.71) | ATP6V1B1ATP6AP1CYP2D6ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903117-B2 | Indole derivatives for the treatment of osteoporosis | NIKEM RESEARCH S.R.L. (IT) | 2005-06-07 | — | — | US | claimed |
| US-6903117-B2 | Indole derivatives for the treatment of osteoporosis | NIKEM RESEARCH S.R.L. (IT) | 2005-06-07 | — | — | US | disclosed |