Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353674 | 0.90 | MAPT (0.61) | MAPTTDP1SMN1; SMN2LMNATSHR | |
| SCHEMBL8353740 | 0.90 | ALDH1A1 (0.53) | MAPTTDP1SMN1; SMN2LMNATSHR | |
| SCHEMBL8350048 | 0.90 | SMN1; SMN2 (0.59) | MAPK1MAPTTDP1SMN1; SMN2LMNA | |
| SCHEMBL8350094 | 0.89 | POLB (0.59) | MAPTTP53LMNATSHRALDH1A1 | |
| SCHEMBL8350476 | 0.89 | ALDH1A1 (0.63) | MAPK1MAPTTP53TDP1LMNA | |
| Acetic Acid SCHEMBL8508080 | 0.88 | MAPT (0.59) | MAPTTDP1SMN1; SMN2LMNATSHR | |
| SCHEMBL8357900 | 0.87 | MAPT (0.55) | MAPK1MAPTTDP1LMNATSHR | |
| SCHEMBL8354260 | 0.86 | TP53 (0.54) | MAPK1MAPTTP53TDP1USP2 | |
| SCHEMBL8358497 | 0.85 | GAA (0.56) | MAPK1MAPTSMN1; SMN2LMNATSHR | |
| SCHEMBL8350533 | 0.82 | POLB (0.57) | MAPTSMN1; SMN2LMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | claimed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |