Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351254 | 0.94 | GAA (0.53) | MAPTMAPK1GAAALDH1A1HTT | |
| SCHEMBL8357900 | 0.89 | MAPT (0.55) | MAPTMAPK1GAAALDH1A1TDP1 | |
| SCHEMBL8350533 | 0.88 | POLB (0.57) | MAPTGAAALDH1A1POLB | |
| SCHEMBL8351239 | 0.86 | MAPK1 (0.63) | TP53MAPTMAPK1USP2ALDH1A1 | |
| SCHEMBL8350635 | 0.83 | MAPT (0.58) | MAPTMAPK1GAAALDH1A1POLB | |
| SCHEMBL8356273 | 0.82 | MAPT (0.54) | MAPTMAPK1GAAALDH1A1TDP1 | |
| SCHEMBL8357958 | 0.82 | MAPT (0.51) | TP53MAPTGAAALDH1A1HTT | |
| SCHEMBL8350306 | 0.82 | SMN1; SMN2 (0.53) | TP53MAPTMAPK1GAAALDH1A1 | |
| SCHEMBL8350094 | 0.82 | POLB (0.59) | TP53MAPTGAAALDH1A1POLB | |
| SCHEMBL8350476 | 0.82 | ALDH1A1 (0.63) | TP53MAPTMAPK1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |