Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354260 | 0.94 | TP53 (0.54) | GAAALDH1A1POLBMAPK1HTT | |
| SCHEMBL8357900 | 0.92 | MAPT (0.55) | GAAALDH1A1POLBMAPK1LMNA | |
| SCHEMBL8350533 | 0.91 | POLB (0.57) | GAASMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL8357958 | 0.85 | MAPT (0.51) | GAASMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL8356273 | 0.85 | MAPT (0.54) | GAAALDH1A1POLBMAPK1LMNA | |
| SCHEMBL8350306 | 0.85 | SMN1; SMN2 (0.53) | GAASMN1; SMN2ALDH1A1POLBMAPK1 | |
| SCHEMBL8350094 | 0.84 | POLB (0.59) | GAAALDH1A1POLBLMNAMEN1 | |
| SCHEMBL8353638 | 0.84 | MAPT (0.52) | GAAALDH1A1POLBMAPK1LMNA | |
| SCHEMBL8350635 | 0.83 | MAPT (0.58) | GAAALDH1A1POLBMAPK1LMNA | |
| SCHEMBL8353674 | 0.82 | MAPT (0.61) | GAASMN1; SMN2ALDH1A1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | claimed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |