Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358497 | 0.90 | GAA (0.56) | MAPTLMNASMN1; SMN2POLBGAA | |
| SCHEMBL8350533 | 0.87 | POLB (0.57) | MAPTLMNASMN1; SMN2POLBGAA | |
| SCHEMBL8357900 | 0.85 | MAPT (0.55) | MAPTLMNAPOLBGAAALDH1A1 | |
| SCHEMBL8353674 | 0.85 | MAPT (0.61) | MAPTLMNASMN1; SMN2POLBGAA | |
| SCHEMBL8351254 | 0.85 | GAA (0.53) | MAPTLMNASMN1; SMN2POLBGAA | |
| SCHEMBL8350476 | 0.83 | ALDH1A1 (0.63) | MAPTLMNATP53POLBGAA | |
| Acetic Acid SCHEMBL8508080 | 0.83 | MAPT (0.59) | MAPTLMNASMN1; SMN2POLBGAA | |
| SCHEMBL8354260 | 0.82 | TP53 (0.54) | MAPTTP53POLBGAAALDH1A1 | |
| SCHEMBL8350094 | 0.82 | POLB (0.59) | MAPTLMNATP53POLBGAA | |
| SCHEMBL8350048 | 0.81 | SMN1; SMN2 (0.59) | MAPTLMNASMN1; SMN2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |