Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351810 | 1.00 | MAPT (0.54) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8351814 | 1.00 | MAPT (0.54) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2561497 | 0.79 | KMT2A (0.54) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2561496 | 0.79 | KMT2A (0.54) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11887857 | 0.77 | MAPT (0.55) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14570850 | 0.77 | KMT2A (0.52) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL870631 | 0.72 | KMT2A (0.59) | MAPTGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8923713 | 0.72 | NFE2L2 (0.58) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL8923719 | 0.72 | NFE2L2 (0.58) | MAPTKMT2AMEN1RAB9AKDM4E | |
| SCHEMBL8921387 | 0.72 | MAPT (0.50) | MAPTRAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981525-A | FOR THERAPY OR PROPHYLAXIS OF OSTEOPOROSIS,TUMOURS, ULCERS, AUTOIMMUNE DISEASES, LIPIDEMIC DISORDERS, HYPERCHOLESTEROLEMIC AND ATHEROSCLEROTIC DISEASES, AIDS ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0802902-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | Smithkline Beecham S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021644-A1 | INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS | SMITHKLINE BEECHAM S.P.A. (IT) | 1996-07-18 | — | — | WO | disclosed |