Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921396 | 1.00 | MAPT (0.50) | MAPTCDK4CCND1KDM4ENPC1 | |
| SCHEMBL8921393 | 1.00 | MAPT (0.50) | MAPTCDK4CCND1KDM4ENPC1 | |
| SCHEMBL8923723 | 0.84 | NFE2L2 (0.58) | MAPTKDM4ENPC1MAPK1RAB9A | |
| SCHEMBL8923719 | 0.84 | NFE2L2 (0.58) | MAPTKDM4ENPC1MAPK1RAB9A | |
| SCHEMBL8923713 | 0.84 | NFE2L2 (0.58) | MAPTKDM4ENPC1MAPK1RAB9A | |
| SCHEMBL8921206 | 0.80 | LMNA (0.54) | MAPTKDM4EMAPK1TDP1LMNA | |
| SCHEMBL8921211 | 0.80 | LMNA (0.54) | MAPTKDM4EMAPK1TDP1LMNA | |
| SCHEMBL8921219 | 0.80 | LMNA (0.54) | MAPTKDM4EMAPK1TDP1LMNA | |
| SCHEMBL8922338 | 0.79 | MAPT (0.58) | MAPTKDM4ENPC1MAPK1RAB9A | |
| SCHEMBL8922348 | 0.79 | MAPT (0.58) | MAPTKDM4ENPC1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802897-A1 | NOVEL COMPOUNDS | Smithkline Beecham S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021638-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM S.P.A. (IT) | 1996-07-18 | — | — | WO | disclosed |