Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353417 | 0.92 | OPRM1 (0.40) | OPRM1OPRL1OPRK1MAOBMAOA | |
| SCHEMBL16361263 | 0.81 | OPRL1 (0.61) | OPRM1OPRL1OPRK1 | |
| SCHEMBL8351738 | 0.78 | OPRM1 (0.67) | OPRM1OPRL1OPRK1MAOBMAOA | |
| SCHEMBL7382859 | 0.72 | OPRL1 (0.50) | OPRM1OPRL1OPRK1 | |
| SCHEMBL11079009 | 0.70 | SLC6A4 (0.38) | OPRM1OPRL1OPRK1 | |
| SCHEMBL11556162 | 0.70 | ESR2 (0.39) | OPRM1OPRL1 | |
| SCHEMBL8352749 | 0.70 | OPRL1 (0.58) | OPRM1OPRL1OPRK1MAOBMAOA | |
| SCHEMBL8353443 | 0.70 | OPRL1 (0.58) | OPRM1OPRL1OPRK1MAOBMAOA | |
| SCHEMBL8351068 | 0.69 | OPRM1 (0.68) | OPRM1OPRL1OPRK1MAOBMAOA | |
| SCHEMBL8350807 | 0.68 | PYCR1 (0.46) | OPRM1OPRL1OPRK1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312214-B2 | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |
| WO-2003099276-A1 | 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-12-04 | — | — | WO | disclosed |